Dataset Information


Cell intrinsic changes in transcription of naïve CD4 T cells upon S1pr1 deletion

ABSTRACT: Naïve CD4 cells (CD45.2+CD4+,CD62L high,CD44 low) isolated from lymph nodes of mixed bone marrow chimeras 5 days after induced S1pr1 deletion. Overall design: CD45.1+ mice were reconstituted with a mix of BM from WT UBC:GFP mice and BM from S1pr1f/fUBC-CreERT2 CD45.2+ mice or littermate controls. S1pr1 was deleted by tamoxifen injection for 5 days. Naïve CD4+ CD62L high CD44 low CD45.2+ GFP- cells were sorted 5 days after last tamoxifen injection.

INSTRUMENT(S): Illumina HiSeq 2500 (Mus musculus)

SUBMITTER: Susan Schwab  

PROVIDER: GSE97249 | GEO | 2017-05-26



altmetric image


Effective adaptive immune responses require a large repertoire of naive T cells that migrate throughout the body, rapidly identifying almost any foreign peptide. Because the production of T cells declines with age, naive T cells must be long-lived. However, it remains unclear how naive T cells survive for years while constantly travelling. The chemoattractant sphingosine 1-phosphate (S1P) guides T cell circulation among secondary lymphoid organs, including spleen, lymph nodes and Peyer's patches  ...[more]

Similar Datasets

| GSE81196 | GEO
2012-10-23 | E-GEOD-41736 | ArrayExpress
2010-06-10 | E-GEOD-8352 | ArrayExpress
2007-07-07 | GSE8352 | GEO
2015-08-05 | E-GEOD-67884 | ArrayExpress
| GSE103142 | GEO
2007-08-06 | E-GEOD-1460 | ArrayExpress
2014-03-14 | E-GEOD-46892 | ArrayExpress
2015-07-13 | E-GEOD-46892 | ExpressionAtlas
2013-06-14 | E-GEOD-47909 | ArrayExpress