Transcriptomics,Genomics

Dataset Information

31

Cell intrinsic changes in transcription of naïve CD4 T cells upon S1pr1 deletion


ABSTRACT: Naïve CD4 cells (CD45.2+CD4+,CD62L high,CD44 low) isolated from lymph nodes of mixed bone marrow chimeras 5 days after induced S1pr1 deletion. Overall design: CD45.1+ mice were reconstituted with a mix of BM from WT UBC:GFP mice and BM from S1pr1f/fUBC-CreERT2 CD45.2+ mice or littermate controls. S1pr1 was deleted by tamoxifen injection for 5 days. Naïve CD4+ CD62L high CD44 low CD45.2+ GFP- cells were sorted 5 days after last tamoxifen injection.

INSTRUMENT(S): Illumina HiSeq 2500 (Mus musculus)

SUBMITTER: Susan Schwab  

PROVIDER: GSE97249 | GEO | 2017-05-26

SECONDARY ACCESSION(S): PRJNA381079

REPOSITORIES: GEO

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Publications


Effective adaptive immune responses require a large repertoire of naive T cells that migrate throughout the body, rapidly identifying almost any foreign peptide. Because the production of T cells declines with age, naive T cells must be long-lived. However, it remains unclear how naive T cells survive for years while constantly travelling. The chemoattractant sphingosine 1-phosphate (S1P) guides T cell circulation among secondary lymphoid organs, including spleen, lymph nodes and Peyer's patches  ...[more]

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