Genomics

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Affymetrix SNP array data for chronic lymphoblastic leukemia samples


ABSTRACT: Ibrutinib (Ibr), an orally administered covalent inhibitor of Bruton’s kinase, has generated remarkable responses in CLL patients including those with an unfavorable cytogenetic profile. Once patients develop resistance to ibrutinib, the outcome is poor with few treatment options. To further understand the genomic mechanisms underlying Ibr resistance, we’ve performed genome wide copy number analysis of serial samples collected from nine ibrutinib-relapsed patients. Deletions of 18p often coincide with del(17p)/TP53 mutations, predispose patients to relapse.

ORGANISM(S): Homo sapiens

PROVIDER: GSE97436 | GEO | 2017/04/06

SECONDARY ACCESSION(S): PRJNA381777

REPOSITORIES: GEO

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