Genomics

Dataset Information

38

Affymetrix SNP array data for chronic lymphoblastic leukemia samples


ABSTRACT: Ibrutinib (Ibr), an orally administered covalent inhibitor of Bruton’s kinase, has generated remarkable responses in CLL patients including those with an unfavorable cytogenetic profile. Once patients develop resistance to ibrutinib, the outcome is poor with few treatment options. To further understand the genomic mechanisms underlying Ibr resistance, we’ve performed genome wide copy number analysis of serial samples collected from nine ibrutinib-relapsed patients. Deletions of 18p often coincide with del(17p)/TP53 mutations, predispose patients to relapse. Overall design: Affymetrix SNP arrays were performed according to the manufacturer's directions on DNA extracted from diagnostic bone marrow, peripheral blood or lymph node samples. Copy number analysis of Affymetrix CytoScan or OncoScan SNP arrays was performed on a total of 26 samples collected from 9 patients included in the study. Please note that OncoScan arrays produce 2 CEL files generated from 2 separate chips that are subsequently converted and combined into one OSCHP file.

INSTRUMENT(S): [CytoScanHD_Array] Affymetrix CytoScan HD Array

SUBMITTER: Carrie A Fitzpatrick 

PROVIDER: GSE97436 | GEO | 2017-04-06

SECONDARY ACCESSION(S): PRJNA381777

REPOSITORIES: GEO

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Publications


Ibrutinib has generated remarkable responses in patients with chronic lymphocytic leukemia (CLL), including those with an unfavorable cytogenetic profile. However, patients develop resistance, with poor outcomes and no established treatment options. Mutations in BTK and PLCG2 have emerged as main mechanisms of drug resistance, but not all patients carry these mutations. Further understanding of mechanisms of resistance is urgently needed and will support rational development of new therapeutic s  ...[more]

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