Genomics

Dataset Information

0

Response to estradiol-ERbeta and estradiol-ERbeta ERE binding defective mutant


ABSTRACT: In addition to the estrogen responsive element (ERE)-dependent gene expression, E2-ERbeta regulates transcription through functional interactions with transfactors bound to their cognate regulatory elements on DNA, hence the ERE-independent signaling pathway. However, the relative importance of the ERE-independent pathway in E2-ERbeta signaling is unclear. Our studies in infected ER-negative cell models with an ERbeta mutant (ERbetaDBD) that functions exclusively at the ERE-independent pathway demonstrated that genomic responses assessed by microarrays from the ERE-independent pathway to E2-ERbeta are not sufficient to alter cellular growth, death or motility. These findings suggest that the ERE-dependent pathway is the canonical E2-ERbeta signaling in model cell lines. Keywords: MDA-MB-231 cells

ORGANISM(S): Homo sapiens

PROVIDER: GSE9759 | GEO | 2007/12/04

SECONDARY ACCESSION(S): PRJNA105109

REPOSITORIES: GEO

Similar Datasets

| E-GEOD-9759 | biostudies-arrayexpress
2007-12-04 | GSE9758 | GEO
| E-GEOD-9761 | biostudies-arrayexpress
2007-12-04 | GSE9757 | GEO
| E-GEOD-9757 | biostudies-arrayexpress
| E-GEOD-9758 | biostudies-arrayexpress
2017-03-01 | GSE86609 | GEO
| E-GEOD-1153 | biostudies-arrayexpress
2010-05-12 | GSE21770 | GEO
| E-GEOD-21770 | biostudies-arrayexpress