Genomics

Dataset Information

158

AHR ChIP-Seq of female mouse liver following 2 hour TCDD exposure


ABSTRACT: Aryl hydrocarbon receptor ChIP-Seq performed in livers of female mice gavaged with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) for 2hrs Overall design: Five biological replicates

INSTRUMENT(S): Illumina HiSeq 2500 (Mus musculus)

SUBMITTER: Timothy R Zacharewski  

PROVIDER: GSE97636 | GEO | 2017-04-12

SECONDARY ACCESSION(S): PRJNA382532

REPOSITORIES: GEO

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Publications

Pyruvate Kinase Isoform Switching and Hepatic Metabolic Reprogramming by the Environmental Contaminant 2,3,7,8-Tetrachlorodibenzo-p-Dioxin.

Nault Rance R   Fader Kelly A KA   Kirby Mathew P MP   Ahmed Shaimaa S   Matthews Jason J   Jones A Daniel AD   Lunt Sophia Y SY   Zacharewski Timothy R TR  

Toxicological sciences : an official journal of the Society of Toxicology 20151117 2


The environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) elicits dose-dependent hepatotoxicity that includes fat accumulation, inflammation, and fibrosis that may progress to hepatocellular carcinoma. To further investigate these effects, RNA-Seq data were integrated with computationally identified putative dioxin response elements, and complementary targeted metabolomic and aryl hydrocarbon receptor (AhR) ChIP-Seq data from female C57BL/6 mice gavaged with TCDD every 4 days for  ...[more]

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