Transcriptomics,Genomics

Dataset Information

155

Differential requirements for Tcf1 long isoforms in CD8+ and CD4+ T cell responses to acute viral infection


ABSTRACT: Comparison of the transcriptome between control Tfh and Tcf1 long isoform-deficient Tfh cells Overall design: SMARTA CD4+ T cells (control or Tcf1 long isoform deficient) were adoptively transferred into B6.SJL recipient mice and then infected with LCMV-Arm. On day 8 after infection, the splenocytes were isolated, and CD45.2+CD4+CXCR5+PD-1 negative cells were sorted as Tfh cells and used in RNAseq analysis.

INSTRUMENT(S): Illumina HiSeq 2000 (Mus musculus)

SUBMITTER: Hai-Hui Xue  

PROVIDER: GSE98347 | GEO | 2017-05-24

SECONDARY ACCESSION(S): PRJNA384796

REPOSITORIES: GEO

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Publications

Differential Requirements for Tcf1 Long Isoforms in CD8+ and CD4+ T Cell Responses to Acute Viral Infection.

Gullicksrud Jodi A JA   Li Fengyin F   Xing Shaojun S   Zeng Zhouhao Z   Peng Weiqun W   Badovinac Vladimir P VP   Harty John T JT   Xue Hai-Hui HH  

Journal of immunology (Baltimore, Md. : 1950) 20170626 3


In response to acute viral infection, activated naive T cells give rise to effector T cells that clear the pathogen and memory T cells that persist long-term and provide heightened protection. T cell factor 1 (Tcf1) is essential for several of these differentiation processes. Tcf1 is expressed in multiple isoforms, with all isoforms sharing the same HDAC and DNA-binding domains and the long isoforms containing a unique N-terminal β-catenin-interacting domain. In this study, we specifically ablat  ...[more]

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