Dataset Information


Expression data in HCT-116 colon cancer cell treated with SCD1 inhibitor or in SCD1 knocked out HCT-116 cell

ABSTRACT: To understand molecular mechanisms underlying the growth inhibitory ativity of Stearoyl-CoA desaturase-1 (SCD1) inhibitor, we performed microarray analysis using HCT-116 colorectal cancer cells, in which SCD1 was pharmacologically blocked or genetically ablated. Overall design: HCT-116 cells treated with DMSO or SCD1 inhibitor, and SCD1 knocked-out cells were harvested for RNA extraction and hybridization on Affymetrix microarray (n = 1 each). The DMSO-treated sample was used as a control.

INSTRUMENT(S): [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array

SUBMITTER: Akito Ono  

PROVIDER: GSE98364 | GEO | 2017-08-01



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Feedback activation of AMPK-mediated autophagy acceleration is a key resistance mechanism against SCD1 inhibitor-induced cell growth inhibition.

Ono Akito A   Sano Osamu O   Kazetani Ken-Ichi KI   Muraki Takamichi T   Imamura Keisuke K   Sumi Hiroyuki H   Matsui Junji J   Iwata Hidehisa H  

PloS one 20170713 7

Elucidating the bioactive compound modes of action is crucial for increasing success rates in drug development. For anticancer drugs, defining effective drug combinations that overcome resistance improves therapeutic efficacy. Herein, by using a biologically annotated compound library, we performed a large-scale combination screening with Stearoyl-CoA desaturase-1 (SCD1) inhibitor, T-3764518, which partially inhibits colorectal cancer cell proliferation. T-3764518 induced phosphorylation and act  ...[more]

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