Transcriptomics,Genomics

Dataset Information

39

Gene expression profiles of PBMCs in healthy subjects (CTRL) and patients with Metabolic Syndrome (MS) - PART 1 - Genes


ABSTRACT: The aim of the present study was to investigate the whole-genome gene and miRNA profiles in MS. Results provide the information of changes in the PBMCs transcriptome in subjects with MS. Overall design: RNA obtained from PBMCs of the CTRL subjects and MS patients. Comparisons: CTRL vs. MS.

INSTRUMENT(S): Illumina HumanHT-12 V3.0 expression beadchip

SUBMITTER: Antonio Moschetta 

PROVIDER: GSE98895 | GEO | 2018-03-28

REPOSITORIES: GEO

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Publications

Identification of miR-9-5p as direct regulator of ABCA1 and HDL-driven reverse cholesterol transport in circulating CD14+ cells of patients with metabolic syndrome.

D'Amore Simona S   Härdfeldt Jennifer J   Cariello Marica M   Graziano Giusi G   Copetti Massimiliano M   Di Tullio Giuseppe G   Piglionica Marilidia M   Scialpi Natasha N   Sabbà Carlo C   Palasciano Giuseppe G   Vacca Michele M   Moschetta Antonio A  

Cardiovascular research 20180701 8


<h4>Aims</h4>Metabolic syndrome (MS) is a cluster of cardio-metabolic risk factors associated with atherosclerosis and low-grade inflammation. Using unbiased expression screenings in peripheral blood mononuclear cells, we depict here a novel expression chart of 678 genes and 84 microRNAs (miRNAs) controlling inflammatory, immune and metabolic responses. In order to further elucidate the link between inflammation and the HDL cholesterol pathway in MS, we focussed on the regulation of the ATP-bind  ...[more]

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