Genomics

Dataset Information

0

RNASeq to identify the in vitro molecular signature of Ox40 signaling in conjunction with TCR signaling in CD4 T cells from NZB/W F1 Mice


ABSTRACT: We've recently shown that we can accelerate disease in a model of SLE (the NZB/W F1 model) using an anti-Ox40 mAb treatment regimen. The disease acceleration is rapid (within 2 weeks) but its unclear, mechanistically, how Ox40 promotes disease. To that end we performed RNASeq on in vitro cultured CD4 T cells during Ox40 and TCR stimulation (in a reductionist setting) to understand how Ox40 signaling impacts cellular phenotype and function, including with and without TCR stimulation

ORGANISM(S): Mus musculus

PROVIDER: GSE99645 | GEO | 2017/08/18

SECONDARY ACCESSION(S): PRJNA389203

REPOSITORIES: GEO

Similar Datasets

2017-08-18 | GSE99646 | GEO
| E-GEOD-32373 | biostudies-arrayexpress
2011-09-26 | GSE32373 | GEO
| E-GEOD-13502 | biostudies-arrayexpress
2018-06-26 | GSE103523 | GEO
2018-05-18 | GSE114568 | GEO
2019-12-31 | GSE105187 | GEO
2009-09-22 | GSE13502 | GEO
2020-12-08 | GSE107908 | GEO
| 2198817 | ecrin-mdr-crc