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MetaboLights MTBLS652 - GNPS Infection-Induced Peroxisome Biogenesis Is a Metabolic Strategy for Herpesvirus Replication

ABSTRACT: Peroxisomes are primarily metabolic organelles with important functions in lipid metabolism, such as fatty acid oxidation and ether phospholipid synthesis (e.g. plasmalogens). Certain viruses, such as human cytomegalovirus (HCMV), hijack organelle functions to facilitate their replication and spread. However, the role of peroxisomes in herpesvirus replication remains elusive. Following a discovery that peroxisome proteins are upregulated upon HCMV infection, we quantified the production of plasmalogens, lipids that require peroxisome functions. In agreement with the increase in peroxisome protein abundance, plasmalogen production was increased by HCMV infection.

INSTRUMENT(S): N/A

ORGANISM(S): Homo Sapiens|9606

SUBMITTER: Ileana Cristea

PROVIDER: MSV000085756 | GNPS | Tue Jul 14 17:19:00 BST 2020

REPOSITORIES: GNPS

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Infection-Induced Peroxisome Biogenesis Is a Metabolic Strategy for Herpesvirus Replication

Project description:Peroxisomes are primarily metabolic organelles with important functions in lipid metabolism, such as fatty acid oxidation and ether phospholipid synthesis (e.g. plasmalogens). Certain viruses, such as human cytomegalovirus (HCMV), hijack organelle functions to facilitate their replication and spread. However, the role of peroxisomes in herpesvirus replication remains elusive. Following a discovery that peroxisome proteins are upregulated upon HCMV infection, we quantified the production of plasmalogens, lipids that require peroxisome functions. In agreement with the increase in peroxisome protein abundance, plasmalogen production was increased by HCMV infection.

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