Metabolomics

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MetaboLights MTBLS652 - GNPS Infection-Induced Peroxisome Biogenesis Is a Metabolic Strategy for Herpesvirus Replication


ABSTRACT: Peroxisomes are primarily metabolic organelles with important functions in lipid metabolism, such as fatty acid oxidation and ether phospholipid synthesis (e.g. plasmalogens). Certain viruses, such as human cytomegalovirus (HCMV), hijack organelle functions to facilitate their replication and spread. However, the role of peroxisomes in herpesvirus replication remains elusive. Following a discovery that peroxisome proteins are upregulated upon HCMV infection, we quantified the production of plasmalogens, lipids that require peroxisome functions. In agreement with the increase in peroxisome protein abundance, plasmalogen production was increased by HCMV infection.

INSTRUMENT(S): N/A

ORGANISM(S): Homo sapiens  

SUBMITTER: Ileana Cristea  

PROVIDER: MSV000085756 | GNPS | Tue Jul 14 17:19:00 BST 2020

REPOSITORIES: GNPS

Dataset's files

Source:
Action DRS
Other
params.xml Xml
Infected_02122018_PJ_A.mzML Mzml
Infected_02122018_PJ_B.mzML Mzml
MRCF5_Mock_A_020718_lipid.mzML Mzml
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