Metabolomics,Multiomics

Dataset Information

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Infection-Induced Peroxisome Biogenesis Is a Metabolic Strategy for Herpesvirus Replication


ABSTRACT: Peroxisomes are primarily metabolic organelles with important functions in lipid metabolism, such as fatty acid oxidation and ether phospholipid synthesis (e.g. plasmalogens). Certain viruses, such as human cytomegalovirus (HCMV), hijack organelle functions to facilitate their replication and spread. However, the role of peroxisomes in herpesvirus replication remains elusive. Following a discovery that peroxisome proteins are upregulated upon HCMV infection, we quantified the production of plasmalogens, lipids that require peroxisome functions. In agreement with the increase in peroxisome protein abundance, plasmalogen production was increased by HCMV infection.

OTHER RELATED OMICS DATASETS IN: PXD009321

INSTRUMENT(S): Liquid Chromatography MS - Positive (LC-MS (Positive))

SUBMITTER: Pierre Jean Beltran 

PROVIDER: MTBLS652 | MetaboLights | 2018-10-22

REPOSITORIES: MetaboLights

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Publications

Infection-Induced Peroxisome Biogenesis Is a Metabolic Strategy for Herpesvirus Replication.

Jean Beltran Pierre M PM   Cook Katelyn C KC   Hashimoto Yutaka Y   Galitzine Cyril C   Murray Laura A LA   Vitek Olga O   Cristea Ileana M IM  

Cell host & microbe 20180927 4


Viral proteins have evolved to target cellular organelles and usurp their functions for virus replication. Despite the knowledge of these critical functions for several organelles, little is known about peroxisomes during infection. Peroxisomes are primarily metabolic organelles with important functions in lipid metabolism. Here, we discovered that the enveloped viruses human cytomegalovirus (HCMV) and herpes simplex virus type 1 (HSV-1) induce the biogenesis of and unique morphological changes  ...[more]

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