Characterization of functional reprogramming during osteoclast development using quantitative proteomics and mRNA profiling.

ABSTRACT: Data from ProteomeXchange, PXD ID: PXD000471. Experiment: 101207_EA_E, file: 101215_EA_E13.mzml. Published as part of . From the Abstract: {{i}} In addition to forming macrophages and dendritic cells, monocytes in adult peripheral blood retain the ability to develop into osteoclasts, mature bone-resorbing cells. The extensive morphological and functional transformation that occurs during osteoclast differentiation requires substantial reprogramming of gene and protein expression. Here we employ -omic scale technologies to examine in detail the molecular changes at discrete developmental stages in this process (precursor cells, intermediate osteoclasts and multinuclear osteoclasts), quantitatively comparing their transcriptomes and proteomes ... {{/i}}

INSTRUMENT(S): Instrument

ORGANISM(S): Mus_musculus_viruses, Mouse

DISEASE(S): Not Available

SUBMITTER: An E, et al.  

PROVIDER: GPM11210028860 | GPMDB |

REPOSITORIES: GPMDB