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Omics score: 1004

Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver.

ABSTRACT: Data from MASSIVE, MSV000078555. Experiment: D120204_CoN_2207, file: D120204_MGH_2207_OGE07_rafkt_ft8dt_cc_01.mzml. Published as part of BMC Cancer. 2014 Jul 18;14(1):518 . From the Abstract: {{i}} We have used enrichment of extracellular matrix (ECM) from human patient samples and proteomics to define the ECM composition of primary colon carcinomas and their metastases to liver in comparison with normal colon and liver samples. {{/i}}

INSTRUMENT(S): Instrument

ORGANISM(S): Homo_sapiens_viruses, Human

DISEASE(S): Not Available

SUBMITTER: Naba A, et al.

PROVIDER: GPM32310002460 | GPMDB |

REPOSITORIES: GPMDB

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Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver.

Naba Alexandra A Clauser Karl R KR Whittaker Charles A CA Carr Steven A SA Tanabe Kenneth K KK Hynes Richard O RO

BMC cancer 20140718

<h4>Background</h4>Colorectal cancer is the third most frequently diagnosed cancer and the third cause of cancer deaths in the United States. Despite the fact that tumor cell-intrinsic mechanisms controlling colorectal carcinogenesis have been identified, novel prognostic and diagnostic tools as well as novel therapeutic strategies are still needed to monitor and target colon cancer progression. We and others have previously shown, using mouse models, that the extracellular matrix (ECM), a major ...[more]

PMID: 25037231

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