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Omics score: 1003

Type 1 Diabetes Prone NOD Mice Have Diminished Cxcr1 mRNA Expression in Polymorphonuclear Neutrophils and CD4+ T Lymphocytes.

ABSTRACT: Data from ProteomeXchange, PXD ID: PXD003015. File: OB07268.mzml. Published as part of PLoS One. 2015 Jul 31;10(7):e0134365 . From the Abstract: {{i}} ... Here, we report descriptive data about the Cxcr1 gene in NOD mice ... {{/i}}

INSTRUMENT(S): Instrument

ORGANISM(S): Mus_musculus_viruses, Mouse

DISEASE(S): Not Available

SUBMITTER: Haurogne K, et al.

PROVIDER: GPM32310024995 | GPMDB |

REPOSITORIES: GPMDB

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Type 1 Diabetes Prone NOD Mice Have Diminished Cxcr1 mRNA Expression in Polymorphonuclear Neutrophils and CD4+ T Lymphocytes.

Haurogné Karine K Pavlovic Marija M Rogniaux Hélène H Bach Jean-Marie JM Lieubeau Blandine B

PloS one 20150731 7

In humans, CXCR1 and CXCR2 are two homologous proteins that bind ELR+ chemokines. Both receptors play fundamental roles in neutrophil functions such as migration and reactive oxygen species production. Mouse Cxcr1 and Cxcr2 genes are located in an insulin-dependent diabetes genetic susceptibility locus. The non obese diabetic (NOD) mouse is a spontaneous well-described animal model for insulin-dependent type 1 diabetes. In this disease, insulin deficiency results from the destruction of insulin- ...[more]

PMID: 26230114

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