Integrin endosomal signalling suppresses anoikis.

ABSTRACT: Data from ProteomeXchange, PXD ID: PXD001870. Experiment: Plasma membrane fraction R2 raw, file: 150120_106.mzml. Published as part of Nat Cell Biol. 2015 Oct 5 . From the Abstract: {{i}} Integrin-containing focal adhesions transmit extracellular signals across the plasma membrane to modulate cell adhesion, signalling and survival. Although integrins are known to undergo continuous endo/exocytic traffic, the potential impact of endocytic traffic on integrin-induced signals is unknown. Here, we demonstrate that integrin signalling is not restricted to cell-ECM adhesions and identify an endosomal signalling platform that supports integrin signalling away from the plasma membrane ... {{/i}}

INSTRUMENT(S): Instrument

ORGANISM(S): Mus_musculus_viruses, Mouse

DISEASE(S): Not Available

SUBMITTER: Alanko J, et al.  

PROVIDER: GPM32310025155 | GPMDB |

REPOSITORIES: GPMDB