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Proteome profiling of breast cancer biopsies reveals a wound healing signature of cancer-associated fibroblasts.

ABSTRACT: Data from ProteomeXchange, PXD ID: PXD001323. Experiment: hmf_cyt_TGFb_1, file: hmf_cyt_TGFb_1_2.mzml. Published as part of J Proteome Res. 2014 Sep 19. . From the Abstract: {{i}} Breast cancer is still the most common type of cancer in women; an important role in carcinogenesis is actually attributed to cancer-associated fibroblasts. In this study we investigated whether it is possible to assess the functional state of cancer-associated fibroblasts through tumor tissue proteome profiling. Tissue proteomics was performed on tumor-central, tumor-near and tumor-distant biopsy sections from breast adenocarcinoma patients, which allowed us to identify 2074 proteins ... {{/i}}

INSTRUMENT(S): Instrument

ORGANISM(S): Homo_sapiens_viruses, Human_female

DISEASE(S): Not Available

SUBMITTER: Groessl M, et al.  

PROVIDER: GPM32320003614 | GPMDB |

REPOSITORIES: GPMDB

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Proteome profiling of breast cancer biopsies reveals a wound healing signature of cancer-associated fibroblasts.

Groessl Michael M   Slany Astrid A   Bileck Andrea A   Gloessmann Kerstin K   Kreutz Dominique D   Jaeger Walter W   Pfeiler Georg G   Gerner Christopher C  

Journal of proteome research 20141003 11

Breast cancer is still the most common type of cancer in women; an important role in carcinogenesis is actually attributed to cancer-associated fibroblasts. In this study, we investigated whether it is possible to assess the functional state of cancer-associated fibroblasts through tumor tissue proteome profiling. Tissue proteomics was performed on tumor-central, tumor-near, and tumor-distant biopsy sections from breast adenocarcinoma patients, which allowed us to identify 2074 proteins. Data we  ...[more]