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Omics score: 1010

Protein degradation and dynamic tRNA thiolation fine-tune translation at elevated temperatures.

ABSTRACT: Data from ProteomeXchange, PXD ID: PXD001864. File: OTV_1309_242.mzXML. Published as part of Nucleic Acids Res. 2015 Apr 13 . From the Abstract: {{i}} Maintenance of protein quality control has implications in various processes such as neurodegeneration and ageing. To investigate how environmental insults affect this process, we analysed the proteome of yeast continuously exposed to mild heat stress. {{/i}}

INSTRUMENT(S): Instrument

ORGANISM(S): Yeast

DISEASE(S): Not Available

SUBMITTER: Tyagi K, et al.

PROVIDER: GPM32320015049 | GPMDB |

REPOSITORIES: GPMDB

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Protein degradation and dynamic tRNA thiolation fine-tune translation at elevated temperatures.

Tyagi Kshitiz K Pedrioli Patrick G A PG

Nucleic acids research 20150413 9

Maintenance of protein quality control has implications in various processes such as neurodegeneration and ageing. To investigate how environmental insults affect this process, we analysed the proteome of yeast continuously exposed to mild heat stress. In agreement with previous transcriptomics studies, amongst the most marked changes, we found up-regulation of cytoprotective factors; a shift from oxidative phosphorylation to fermentation; and down-regulation of translation. Importantly, we also ...[more]

PMID: 25870413

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