Ontology highlight
ABSTRACT:
INSTRUMENT(S): Instrument
ORGANISM(S): Actinoplanes_sp_se50_110
DISEASE(S): Not Available
SUBMITTER: Wendler S, et al.
PROVIDER: GPM32320019694 | GPMDB |
REPOSITORIES: GPMDB
Wendler Sergej S Otto Andreas A Ortseifen Vera V Bonn Florian F Neshat Armin A Schneiker-Bekel Susanne S Walter Frederik F Wolf Timo T Zemke Till T Wehmeier Udo F UF Hecker Michael M Kalinowski Jörn J Becher Dörte D Pühler Alfred A
Journal of proteomics 20150418
Acarbose is an α-glucosidase inhibitor produced by Actinoplanes sp. SE50/110 that is medically important due to its application in the treatment of type2 diabetes. In this work, a comprehensive proteome analysis of Actinoplanes sp. SE50/110 was carried out to determine the location of proteins of the acarbose (acb) and the putative pyochelin (pch) biosynthesis gene cluster. Therefore, a comprehensive state-of-the-art proteomics approach combining subcellular fractionation, shotgun proteomics and ...[more]