Ontology highlight
ABSTRACT:
ORGANISM(S): Drosophila Melanogaster
SUBMITTER: Yaoyang Zhang
PROVIDER: PXD013387 | iProX | Wed Jun 19 00:00:00 BST 2019
REPOSITORIES: iProX
Yang Lu L Cao Ye Y Zhao Jing J Fang Yanshan Y Liu Nan N Zhang Yaoyang Y
Molecular & cellular proteomics : MCP 20190821 10
Aging is characterized by a gradual deterioration in proteome. However, how protein dynamics that changes with normal aging and in disease is less well understood. Here, we profiled the snapshots of aging proteome in <i>Drosophila</i>, from head and muscle tissues of post-mitotic somatic cells, and the testis of mitotically-active cells. Our data demonstrated that dysregulation of proteome homeostasis, or proteostasis, might be a common feature associated with age. We further used pulsed metabol ...[more]