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Phosphoproteomics reveals key regulatory kinases and modulated pathways involved in tumorigenesis of ovarian cancer

ABSTRACT: The present study comprehensively revealed the molecular characteristics in relation to OC and identified significantly distinct phosphorylated sites and phosphorylated proteins underlying the syndrome. The results here dissected regulatory elements (especially kinases) and pathways involved in cancer-related pathways including fructose & mannose metabolism, MAPK, ErbB, and ErbB signaling pathway. These findings may not only provide potential biomarkers and novel therapeutic targets for OC, but also bolstered our knowledge on the physiopathology of this syndrome.

ORGANISM(S): Homo Sapiens

SUBMITTER: Jinghe Lang

PROVIDER: PXD016183 | iProX | Tue Dec 31 00:00:00 GMT 2019

REPOSITORIES: iProX

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Phosphoproteomics Reveals Key Regulatory Kinases and Modulated Pathways Associated with Ovarian Cancer Tumors.

Hu Yingchao Y Sun Lejia L Zhang Yinglan Y Lang Jinghe J Rao Jun J

OncoTargets and therapy 20200429

<h4>Background</h4>Ovarian cancer (OC) is the seventh most common cancer worldwide for women. However, there are no sufficient diagnostic methods and few treatment options available due to poor understanding of its pathogenic mechanisms.<h4>Methods</h4>To comprehensively analyze the phosphoproteomic characterization for OC, we took advantage of a quantitative global phosphoproteomics method, titanium(IV) immobilized metal affinity chromatography (Ti<sup>4+</sup>-IMAC) coupled to nanoscale liquid ...[more]

PMID: 32425555

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