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Quantitative Proteomics Reveals the Development of HBV-associated Glomerulonephritis Triggered by the Down-regulation of SLC7A7

ABSTRACT: As a hepadnavirus, hepatitis B virus (HBV) can cause damage to extrahepatic organs. The kidney is one of the organs that is more susceptible to damage. Researches on HBV-associated glomerulonephritis (HBV-GN) have been going on for decades. But the underlying molecular mechanism remains obscure. Here, we applied tandem mass tag (TMT) isobaric labeled-based method to study the protein profile of the kidney of HBV transgenic mice to illustrate the pathological mechanisms of HBV-GN. We compared a series of proteome samples from 6- and 12-month old HBV transgenic mice and their nontransgenic wild-type (WT) littermates.

ORGANISM(S): Mus Musculus

SUBMITTER: Ping Xu

PROVIDER: PXD016450 | iProX | Wed Nov 27 00:00:00 GMT 2019

REPOSITORIES: iProX

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Quantitative Proteomics Reveals the Development of HBV-Associated Glomerulonephritis Triggered by the Downregulation of SLC7A7.

Zuo Tao T Chen Peiru P Jing Sha S Zhang Tao T Chang Lei L Xu Feng F Zhao Chao C Xu Ping P

Journal of proteome research 20200319 4

As a hepadnavirus, hepatitis B virus (HBV) can cause damage to extrahepatic organs. The kidney is one of the organs that is more susceptible to damage. Research studies on HBV-associated glomerulonephritis (HBV-GN) have been going on for decades. However, the underlying molecular mechanism remains obscure. Here, we applied a tandem mass tag (TMT) isobaric labeling-based method to quantitatively profile the kidney proteome of HBV transgenic mice to illustrate the pathological mechanisms of HBV-GN ...[more]

PMID: 32155069

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