Dataset Information
Human PFKFB3 immunoprecipitates LC-MS/MS Raw DATA
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo Sapiens
SUBMITTER: 
Ting Wang
PROVIDER: PXD016644 | iProX | Mon Dec 09 00:00:00 GMT 2019
REPOSITORIES: iProX
Publications
O-GlcNAcylation of PFKFB3 is required for tumor cell proliferation under hypoxia.
Oncogenesis 20200214 2
The protein O-GlcNAcylation catalysed by O-GlcNAc transferase (OGT) is tightly regulated by glucose availability. It is upregulated and essential for tumor cell proliferation under hypoxic conditions. However, the mechanism behind is still unclear. Here, we showed that the glycolytic regulator 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB3), which also promotes cell cycle progression in the nucleus, was O-GlcNAcylated in response to hypoxia. The O-GlcNAcylation of PFKFB3 could comp ...[more]
