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The novel cereblon modulator CC-885 inhibits mitophagy via selective degradation of BNIP3L

ABSTRACT: Here, by state-of-the-art mass spectrometry-based quantitative proteomic technology, we systematically screened the potential neo-substrates of a novel thalidomide derived cereblon modulator CC-885.

ORGANISM(S): Homo Sapiens

SUBMITTER: Minjia Tan

PROVIDER: PXD017071 | iProX | Sat Jan 11 00:00:00 GMT 2020

REPOSITORIES: iProX

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The novel cereblon modulator CC-885 inhibits mitophagy via selective degradation of BNIP3L.

Hao Bing-Bing BB Li Xiao-Jing XJ Jia Xing-Long XL Wang Yu-Xing YX Zhai Lin-Hui LH Li Duan-Zhuo DZ Liu Jie J Zhang Die D Chen Yu-Lu YL Xu Yong-Hu YH Lee Sang-Kyu SK Xu Guo-Feng GF Chen Xiao-Hua XH Dang Yong-Jun YJ Liu Bin B Tan Min-Jia MJ

Acta pharmacologica Sinica 20200324 9

Mitophagy is a degradative pathway that mediates the degradation of the entire mitochondria, and defects in this process are implicated in many diseases including cancer. In mammals, mitophagy is mediated by BNIP3L (also known as NIX) that is a dual regulator of mitochondrial turnover and programmed cell death pathways. Acute myeloid leukemia (AML) cells with deficiency of BNIP3L are more sensitive to mitochondria-targeting drugs. But small molecular inhibitors for BNIP3L are currently not avail ...[more]

PMID: 32210356

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