Peptidome analysis of cerebrospinal fluid in neonates with hypoxic-ischemic brain damage

ABSTRACT: Hypoxic-ischemic brain injury (HIBD) causes neonatal death and serious neurological disability; however, there are currently no promising therapies for it excepting cooling. Therefore, in this study, we used peptidome analysis to identify differentially expressed peptides in cerebrospinal fluid (CSF) of neonates with HIBD or controls, which may give a foundation for finding new promising drugs of neonatal HIBD. CSF samples were collected from neonates with HIBD (n=4) or controls (n=4). ITRAQ LC-MS/MS was used to identify differentially expressed peptides between two groups.

ORGANISM(S): Homo Sapiens

SUBMITTER: Jie Qiu  

PROVIDER: PXD017797 | iProX | Sun Mar 01 00:00:00 GMT 2020

REPOSITORIES: iProX