Proteomics

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Proteomics Characterization of COVID-19 lung tissues

ABSTRACT: The COVID-19 pandemic has emerged as a global health emergency due to its association with severe pneumonia and relative high mortality. However, the molecular characteristics and pathological features underlying COVID-19 pneumonia remain largely unknown. To characterize molecular mechanisms underlying COVID-19 pathogenesis in the lung tissue using a proteomic approach, fresh lung tissues were obtained from newly deceased patients with COVID-19 pneumonia. After virus inactivation, a quantitative proteomic approach combined with bioinformatics analysis was used to detect proteomic changes in the SARS-CoV-2 infected lung tissues. We identified significant differentially expressed proteins involved in a variety of fundamental biological processes including cellular metabolism, blood coagulation, immune response, angiogenesis, and cell microenvironment regulation. Several inflammatory factors were up-regulated, which was possibly caused by the activation of NF-κB signaling. Extensive dysregulation of the lung proteome in response to SARS-CoV-2 infection was discovered. Our results systematically outlined the molecular pathological features in terms of the lung response to SARS-CoV-2 infection, and provided the scientific basis for the therapeutic target that is urgently needed to control the COVID-19 pandemic.

ORGANISM(S): Homo Sapiens

SUBMITTER: Wu Zhong  

PROVIDER: PXD018094 | iProX | Thu Mar 19 00:00:00 GMT 2020

REPOSITORIES: iProX

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Publications

Pathological features of COVID-19-associated lung injury: a preliminary proteomics report based on clinical samples.

Leng Ling L   Cao Ruiyuan R   Ma Jie J   Mou Danlei D   Zhu Yunping Y   Li Wei W   Lv Luye L   Gao Dunqin D   Zhang Shikun S   Gong Feng F   Zhao Lei L   Qiu Bintao B   Xiang Haiping H   Hu Zhongjie Z   Feng Yingmei Y   Dai Yan Y   Zhao Jiang J   Wu Zhihong Z   Li Hongjun H   Zhong Wu W  

Signal transduction and targeted therapy 20201015 1

The COVID-19 pandemic has emerged as a global health emergency due to its association with severe pneumonia and relative high mortality. However, the molecular characteristics and pathological features underlying COVID-19 pneumonia remain largely unknown. To characterize molecular mechanisms underlying COVID-19 pathogenesis in the lung tissue using a proteomic approach, fresh lung tissues were obtained from newly deceased patients with COVID-19 pneumonia. After virus inactivation, a quantitative  ...[more]