Proteomics

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The Analysis of Plasma Metabolome and Lipidome of Patients with COVID-19

ABSTRACT: The ongoing outbreak of novel coronavirus (SARS-CoV-2) disease 2019 (COVID-19) has been declared a pandemic by the World Health Organization. This disease is marked by its rapid progression from mild to severe conditions, particularly in the absence of adequate medical care. And the mortality rate of COVID-19 in critically ill cases can reach over 60%. However, the physiological changes associated with COVID-19 progress under different conditions are barely understood. In this study, we performed untargeted metabolomics and lipidomic analyses of plasma from COVID-19 patients. We found a positive correlation between the alteration of metabolites and the course of disease deterioration in COVID-19 patients, indicating that the development of disease affects the metabolism of metabolites.

ORGANISM(S): Homo Sapiens

SUBMITTER: Yang Qiu  

PROVIDER: PXD018307 | iProX | Tue Mar 31 00:00:00 BST 2020

REPOSITORIES: iProX

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Publications

SARS-CoV-2 infection causes immunodeficiency in recovered patients by downregulating CD19 expression in B cells via enhancing B-cell metabolism.

Jing Yukai Y   Luo Li L   Chen Ying Y   Westerberg Lisa S LS   Zhou Peng P   Xu Zhiping Z   Herrada Andrés A AA   Park Chan-Sik CS   Kubo Masato M   Mei Heng H   Hu Yu Y   Lee Pamela Pui-Wah PP   Zheng Bing B   Sui Zhiwei Z   Xiao Wei W   Gong Quan Q   Lu Zhongxin Z   Liu Chaohong C  

Signal transduction and targeted therapy 20210922 1

The SARS-CoV-2 infection causes severe immune disruption. However, it is unclear if disrupted immune regulation still exists and pertains in recovered COVID-19 patients. In our study, we have characterized the immune phenotype of B cells from 15 recovered COVID-19 patients, and found that healthy controls and recovered patients had similar B-cell populations before and after BCR stimulation, but the frequencies of PBC in patients were significantly increased when compared to healthy controls bef  ...[more]

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