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Integrated Proteomics Characterization of SARS-CoV-2 Associated Liver Injury

ABSTRACT: The high incidence of liver injury in patients with COVID-19 and the need for long-term medication for recovery make it imperative to study the infectivity and pathogenicity of SARS-CoV-2 in the liver. Here, we have identified significant proteomic changes for the first time in the liver of patients with COVID-19 using a quantitative proteomics approach. We detected differential expression levels of several proteins that mediate characteristic cellular host responses elicited by SARS-CoV-2 infection. These findings reveal important molecular mechanisms that may play a key role in the pathogenesis of COVID-19 associated liver diseases and provide a scientific basis for medical intervention strategy and drug target selection.

ORGANISM(S): Homo Sapiens

SUBMITTER: Wu Zhong

PROVIDER: PXD019968 | iProX | Tue Jun 23 00:00:00 BST 2020

REPOSITORIES: iProX

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Pathological features of COVID-19-associated liver injury-a preliminary proteomics report based on clinical samples.

Leng Ling L Cao Ruiyuan R Ma Jie J Lv Luye L Li Wei W Zhu Yunping Y Wu Zhihong Z Wang Manli M Zhou Yiwu Y Zhong Wu W

Signal transduction and targeted therapy 20210108 1

PMID: 33419962

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