Proteomics

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Proteomic analysis of protein ubiquitination events in human primary and metastatic colon adenocarcinoma tissues

ABSTRACT: Protein ubiquitination is essential for multiple physiological processes through regulating the stability or function of target proteins and has been found to play critical roles in human cancers. However, the protein ubiquitination profile of human metastatic colon adenocarcinoma tissue has not been elucidated yet. In this study, a proprietary ubiquitin branch (K-ε-GG) antibody-based label-free quantitative proteomics and bioinformatics were performed to identify the global protein ubiquitination profile between human primary (Colon) and metastatic colon adenocarcinoma (Meta) tissues.

ORGANISM(S): Homo Sapiens

SUBMITTER: Yi Zhang  

PROVIDER: PXD020597 | iProX | Mon Jul 27 00:00:00 BST 2020

REPOSITORIES: iProX

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Proteomic Analysis of Protein Ubiquitination Events in Human Primary and Metastatic Colon Adenocarcinoma Tissues.

Zhang Yi Y   Chen Cong C   Yu Tingting T   Chen Tao T  

Frontiers in oncology 20200910

Protein ubiquitination is essential for multiple physiological processes through regulating the stability or function of target proteins and has been found to play critical roles in human cancers. However, the protein ubiquitination profile of human metastatic colon adenocarcinoma tissue has not been elucidated yet. In this study, a proprietary ubiquitin branch (K-ε-GG) antibody-based label-free quantitative proteomics and bioinformatics were performed to identify the global protein ubiquitinati  ...[more]

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