Proteomics

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Deletion of vp0057 impacts the proteome profile in Vibrio parahaemolyticus

ABSTRACT: Using bioinformatics analysis, we found that VP0057 may be a potential Ser/Thr protein kinase with phosphorylation activity. Thus, we constructed the vp0057-deletion mutant (∆vp0057) from the wild-type V. parahaemolyticus serotype O3:K6 and employed a mass spectrometry-based proteomic strategy to characterize proteome-wide changes in response to vp0057 deletion. One hundred ninety-seven differentially expressed proteins were identified in the ∆vp0057 strain compared with the wild-type strain, among which 135 proteins were upregulated and 62 proteins were downregulated.

ORGANISM(S): Vibrio Parahaemolyticus Rimd 2210633

SUBMITTER: Jianyi Pan  

PROVIDER: PXD021775 | iProX | Wed Sep 30 00:00:00 BST 2020

REPOSITORIES: iProX

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Deletion of <i>vp0057</i>, a Gene Encoding a Ser/Thr Protein Kinase, Impacts the Proteome and Promotes Iron Uptake and Competitive Advantage in <i>Vibrio parahaemolyticus</i>.

Ye Chen C   Ge Yongze Y   Zhang Yue Y   Zhou Lantian L   Chen Wei W   Zhu Xuan X   Pan Jianyi J  

Journal of proteome research 20201028 1

The marine bacterial pathogen <i>Vibrio parahaemolyticus</i> is a major cause of food-borne gastroenteritis. Recent findings have demonstrated that protein phosphorylation is fundamental to the regulation of many physiological processes in pathogenic bacteria, including bacterial virulence. However, the underlying mechanisms remain to be completely clarified. Using bioinformatics analysis, we found that VP0057 may be a potential Ser/Thr protein kinase with phosphorylation activity. Thus, we cons  ...[more]

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