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Comprehensive kinomic study via a chemical proteomic approach reveals dynamic kinome reprogramming in hepatocellular carcinoma tissues

ABSTRACT: To identify kinases of potential therapeutic interest in HCC, a quantitative kinomic study of tumour and adjacent non-tumour liver tissues was performed using a chemical proteomic approach.

ORGANISM(S): Homo Sapiens

SUBMITTER: Kun He

PROVIDER: PXD023806 | iProX | Tue Jan 26 00:00:00 GMT 2021

REPOSITORIES: iProX

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Comprehensive kinomic study via a chemical proteomic approach reveals kinome reprogramming in hepatocellular carcinoma tissues.

Wang Shufeng S Wang Xinzheng X Yang Xin X Liu Feng F Li Jin J Li Weihua W Bai Zhaofang Z Wang Hongbo H Mao Jie J Li Tingting T He Kun K Wang Hongxia H

Proteomics 20220103 4

Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. Kinases are attractive therapeutic targets since they are commonly altered in cancers. Here, to identify kinases of potential therapeutic interest in HCC, a quantitative kinomic study of tumour and adjacent non-tumour liver tissues was performed using a chemical proteomics approach. In total, 124 kinases were found differentially expressed and they were distributed over all nine kinase groups. Exploration of The Cancer G ...[more]

PMID: 34932872

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