Proteomic signatures in chronic obstructive pulmonary disease emphysematous phenotype

ABSTRACT: Chronic obstructive pulmonary disease (COPD) is a highly heterogeneous disease. Emphysematous phenotype is a type of most common and critical phenotype, which is characterized by progressive lung destruction and poor prognosis. However, the underlying mechanism of this structural damage has not been completely elucidated. A total of 12 patients with COPD emphysematous phenotype (COPD-E) and 9 patients with COPD non-emphysematous phenotype (COPD-NE) were enrolled to determine differences in differential abundant protein (DAP) expression between both groups. Quantitative tandem mass tag-based proteomics was performed on lung tissue samples of all patients.

ORGANISM(S): Homo Sapiens

SUBMITTER: Li Zhao  

PROVIDER: PXD023900 | iProX | Sun Jan 31 00:00:00 GMT 2021

REPOSITORIES: iProX