Ontology highlight
ABSTRACT:
ORGANISM(S): Homo Sapiens
SUBMITTER: Hui Zhang
PROVIDER: PXD024172 | iProX | Tue Feb 09 00:00:00 GMT 2021
REPOSITORIES: iProX
Ma Xiancai X Chen Tao T Peng Zhilin Z Wang Ziwen Z Liu Jun J Yang Tao T Wu Liyang L Liu Guangyan G Zhou Mo M Tong Muye M Guan Yuanjun Y Zhang Xu X Lin Yingtong Y Tang Xiaoping X Li Linghua L Tang Zhonghui Z Pan Ting T Zhang Hui H
The EMBO journal 20210319 10
HIV-1 latency is a major obstacle to achieving a functional cure for AIDS. Reactivation of HIV-1-infected cells followed by their elimination via immune surveillance is one proposed strategy for eradicating the viral reservoir. However, current latency-reversing agents (LRAs) show high toxicity and low efficiency, and new targets are needed to develop more promising LRAs. Here, we found that the histone chaperone CAF-1 (chromatin assembly factor 1) is enriched on the HIV-1 long terminal repeat ( ...[more]