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Proteomics of monocytes stimulated by Candida albicans

ABSTRACT: As innate immune cells, monocytes play a central role in antifungal immunity. Using proteome studies in primary human monocytes, which were stimulated by Candida albicans (yeast) in vitro. Here we describe the changes of proteins in monocytes and demonstrate that in the early stage of infection, the differences of innate immune response triggered by C. albicans over time.

ORGANISM(S): Homo Sapiens

SUBMITTER: Yingchun Xu

PROVIDER: PXD024515 | iProX | Thu Mar 04 00:00:00 GMT 2021

REPOSITORIES: iProX

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GLUT3 as an Intersection of Glycerophospholipid Metabolism and the Innate Immune Response to <i>Candida albicans</i>.

Wu Xian X Zhang Ge G Yang Wen-Hang WH Cui Jing-Tao JT Zhang Li L Xiao Meng M Xu Ying-Chun YC

Frontiers in cellular and infection microbiology 20210618

Immune cells can optimize the management of metabolic resources to balance their energy requirements in order to regulate immune responses. The interconnection between immunometabolism and fungal infections is becoming increasingly apparent. Using proteome and metabolome assays, we found that stimulation of primary human monocytes by <i>Candida albicans</i> was accompanied by upregulation of glucose transporter 3 (GLUT3) and activation of the glycerophospholipid metabolism pathway. Upregulated G ...[more]

PMID: 34222036

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