Targeting IFN-γ-inducible lysosomal thiol reductase Overcomes Chemoresistance in AML through Regulating the ROS-mediated mitochondrial damage
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo Sapiens
SUBMITTER: 
Xiao-Jun Huang
PROVIDER: PXD025114 | iProX | Wed Mar 31 00:00:00 BST 2021
REPOSITORIES: iProX
Publications
Targeting IFN-γ-inducible lysosomal thiol reductase overcomes chemoresistance in AML through regulating the ROS-mediated mitochondrial damage.
Niu Li-Ting LT Wang Yu-Qing YQ Wong Catherine C L CCL Gao Shuai-Xin SX Mo Xiao-Dong XD Huang Xiao-Jun XJ
Translational oncology 20210709 9
The persistence of leukemia stem cells (LSCs) is one of the leading causes of chemoresistance in acute myeloid leukemia (AML). To explore the factors important in LSC-mediated resistance, we use mass spectrometry to screen the factors related to LSC chemoresistance and defined IFN-γ-inducible lysosomal thiol reductase (GILT) as a candidate. We found that the GILT expression was upregulated in chemoresistant CD34+ AML cells. Loss of function studies demonstrated that silencing of GILT in AML cell ...[more]
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Created by COPASI 4.26 (Build 213)
This model is described in the article:
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Abstract:
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Please refer to CC0 Public Domain Dedication for more information.
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