Targeting IFN-γ-inducible lysosomal thiol reductase Overcomes Chemoresistance in AML through Regulating the ROS-mediated mitochondrial damage

ABSTRACT: Our work demonstrated that the inhibition of GILT increases AML chemo-sensitivity through elevating ROS level and induce oxidative mitochondrial damage-mediated apoptosis, and inhibition of the PI3K/Akt/NRF2 pathway enhances the intracellular oxidative state by disrupting redox homeostasis. Our study provides a potentially effective way to overcome chemoresistance of AML.

ORGANISM(S): Homo Sapiens

SUBMITTER: Xiao-Jun Huang  

PROVIDER: PXD025114 | iProX | Wed Mar 31 00:00:00 BST 2021

REPOSITORIES: iProX