The protective effect of Liquiritin in hypoxia/reoxygenation-induced disruption on blood brain barrier

ABSTRACT: Stroke is the second leading cause of death in human life health, but current treatment strategies are limited to thrombolytic therapy, and because of the tight time window, many contraindications, and only a very small number of people can benefit from it, new therapeutic strategies are needed to solve this problem. As a physical barrier between the central nervous system and blood, the blood-brain barrier (BBB) maintains the homeostasis of the central nervous system. Maintaining the integrity of the BBB may emerge as a new therapeutic strategy. Liquiritin (LQ) is a flavonoid isolated from the medicinal plant Glycyrrhiza uralensis, and this study aims to investigate the protective effects of LQ on brain microvascular endothelial cells (BMECs), to provide a new therapeutic strategy for stroke treatment, and also to provide research ideas for the development of traditional Chinese medicine (TCM).

ORGANISM(S): Homo Sapiens

SUBMITTER: Mengting Li  

PROVIDER: PXD025605 | iProX | Sun Apr 25 00:00:00 BST 2021

REPOSITORIES: iProX