Ontology highlight
ABSTRACT:
ORGANISM(S): Larimichthys Crocea
SUBMITTER: Qinghui Ai
PROVIDER: PXD027084 | iProX | Sat Jul 03 00:00:00 BST 2021
REPOSITORIES: iProX
Chen Qiang Q Du Jianlong J Cui Kun K Fang Wei W Zhao Zengqi Z Chen Qiuchi Q Mai Kangsen K Ai Qinghui Q
iScience 20211007 11
Acetylation coordinates many biological processes to ensure cells respond appropriately to nutrients. However, how acetylation regulates lipid surplus-induced inflammation remains poorly understood. Here, we found that a high-fat diet (HFD) enhanced mitochondrial fatty acid β-oxidation, which enhanced acetyl-CoA levels in the liver of the large yellow croaker. The HFD activated ACLY to govern the "citrate transport" to transfer acetyl-CoA from the mitochondria to the nucleus. Elevated acetyl-CoA ...[more]