Ontology highlight
ABSTRACT:
ORGANISM(S): Homo Sapiens
SUBMITTER: Pingping Jiang
PROVIDER: PXD028042 | iProX | Fri Aug 20 00:00:00 BST 2021
REPOSITORIES: iProX
Xu Chengxian C Yang Chenxi C Ye Qing Q Xu Jie J Tong Lingxiao L Zhang Yuchen Y Shen Huijun H Lu Zhihong Z Wang Jingjing J Lai Enyin E Mao Jianhua J Jiang Pingping P
Frontiers in medicine 20211216
Autosomal recessive polycystic kidney disease (ARPKD) is a severe renal cystic disease caused mainly by the polycystic kidney and hepatic disease 1 (<i>PKHD1)</i>. However, the genetic cause, pathologic features, and mechanism of action of ARPKD are not well known. Here, we identified a family with ARPKD. Two siblings harbored biallelic variants in <i>PKHD1</i> (c.7205G>A, c.7973T>A). We determined that the "<i>de novo</i>" variant, c.7205G>A, arose from the mosaicism of the father and had a 7.4 ...[more]