Expression profiling of Pkd1cko mice: A model of Polycystic Kidney Disease

ABSTRACT: Polycystic Kidney Disease (PKD) is a genetic disease of the kidney characterized by the gradual replacement of normal kidney parenchyma by fluid-filled cysts and fibrotic tissue. Autosomal Dominant Polycystic Kidney Disease (ADPKD) is caused by mutations in the PKD1 or PKD2 gene. Here we present an RNASeq experiment designed to investigate the effect of a kidney specific and Tamoxifen inducible knockout of the Pkd1 gene in mice. 7 mice were grouped into two groups, 4 Tamoxifen treated mice which develop an adult onset Polycystic Kidney Disease phenotype and 3 untreated mice which have WT phenotype.

INSTRUMENT(S): Ion Torrent Proton

ORGANISM(S): Mus musculus

SUBMITTER: Tareq Malas 

PROVIDER: E-MTAB-4086 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress