Ontology highlight
ABSTRACT:
ORGANISM(S): Homo Sapiens
SUBMITTER: Zhenghong Yuan
PROVIDER: PXD028190 | iProX | Tue Aug 31 00:00:00 BST 2021
REPOSITORIES: iProX
Zai Wenjing W Hu Kongying K Ye Jianyu J Ding Jiahui J Huang Chao C Li Yaming Y Fang Zhong Z Wu Min M Wang Cong C Chen Jieliang J Yuan Zhenghong Z
Microbiology spectrum 20220216 1
Chronic infection of hepatitis B virus (HBV) remains a major health burden worldwide. While the immune response has been recognized to play crucial roles in HBV pathogenesis, the direct cytopathic effects of HBV infection and replication on host hepatocytes and the HBV-host interactions are only partially defined due to limited culture systems. Here, based on our recently developed 5 chemical-cultured primary human hepatocytes (5C-PHHs) model that supports long-term HBV infection, we performed m ...[more]