Toxicokinetics of arenobufagin and its cardiotoxicity mechanism exploration based on lipidomics and proteomics approaches in rats

ABSTRACT: In this study, the hearts used for proteomics analysis were obtained from rats randomly divided into three groups (6 rats in each group): a control group (a mixture of propanediol and sodium chloride solution), a low-dose ArBu group (ArBu suspension 60 mg/kg) and a high-dose ArBu group (ArBu suspension 120 mg/kg). After a 12 h fast, the rats were intragastrically administered with or without arenobufagin suspension for 2 h. Proteomics and PRM analysis were used for the exploration of cardiotoxicity mechanism.

ORGANISM(S): Rattus Norvegicus

SUBMITTER: Haiyu Zhao  

PROVIDER: PXD028622 | iProX | Fri Sep 17 00:00:00 BST 2021

REPOSITORIES: iProX