A Mechanistic Study on the Synergistic Antihypertensive Effects of Dendrobium officinale Compound Combined with Conventional Antihypertensive Drugs in Spontaneously Hypertensive Rats, Based on Metabolomics

ABSTRACT: This dataset comprises metabolomic profiling data of serum and gut metabolites from 6 female Wistar rats and 42 female spontaneously hypertensive rats (SHR). Six Wistar rats were assigned to the normal control group (Normal), and 42 SHR rats were randomly divided into seven groups with six rats in each group: model group (Model), low-dose Dendrobium mixture group (LF), medium-dose Dendrobium mixture group (MF), high-dose Dendrobium mixture group (HF), irbesartan group (IRB), dual antihypertensive drug combination group (IAC), and herbal formula combined with dual antihypertensive drugs group (FIAC). The gavage volume for all groups was 2 mL/100 g body weight, administered once daily for six consecutive weeks. Rats in the LF, MF, and HF groups received the crude herbal formula at doses of 0.7 g/kg, 1.4 g/kg, and 2.8 g/kg, respectively. The IRB group received irbesartan at 15 mg/kg, the IAC group received a combination of irbesartan (15 mg/kg) and amlodipine (0.5 mg/kg), and the FIAC group received the herbal formula (2.8 g/kg) plus irbesartan (15 mg/kg) and amlodipine (0.5 mg/kg). The Normal and Model groups were administered an equivalent volume of physiological saline.

INSTRUMENT(S): Liquid Chromatography MS - negative - reverse-phase, Liquid Chromatography MS - positive - reverse-phase

PROVIDER: MTBLS14513 | MetaboLights | 2026-05-18

REPOSITORIES: MetaboLights