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Proteomics profiling of major porin deficient Klebsiella pneumoniae in response to ertapenem treatment

ABSTRACT: The ertapenem-resistant K. pneumoniae strain 2018B120 with major porin loss was isolated from a clinical patient, comprehensive genomics and proteomics analysis were conducted.

ORGANISM(S): Klebsiella Pneumoniae Jh1

SUBMITTER: Dingqiang Chen

PROVIDER: PXD030432 | iProX | Mon Aug 14 00:00:00 GMT+01:00 2023

REPOSITORIES: iProX

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Proteomics profiling of ertapenem challenged major porin deficient carbapenem-resistant Klebsiella pneumoniae.

Yuan Pei-Bo PB Ling Jia-Hui JH Zhu Jia-Hui JH Peng Chen C Chen En-Zhong EZ Zhong Yu-Xia YX Liu Wan-Ting WT Wang Lin-Jing LJ Yang Ling L Chen Ding-Qiang DQ

Journal of proteomics 20220902

Carbapenem-resistant Klebsiella pneumoniae (CRKP) is an urgent threat to human health. Major outer membrane proteins (OMPs) porin mutation is one important resistance mechanism of CRKP, and may also affect the inhibition activity of β-lactam and β-lactamase inhibitor combinations. The ertapenem-resistant K. pneumoniae strain 2018B120 with major porin mutations was isolated from a clinical patient. Genomic and time-series proteomic analyses were conducted to retrieve the ertapenem-challenged resp ...[more]

PMID: 36058541

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