Oxygen-sensitive methylation of ULK1 is required for hypoxia-induced autophagy

ABSTRACT: Hypoxia is a physiological stress that frequently occurs in solid tissues. Autophagy, a ubiquitous degradation/recycling system in eukaryotic cells, renders cells tolerant to multiple stressors. However, the mechanisms underlying autophagy initiation upon hypoxia remains unclear. This study identifies an oxygen-sensitive methylation of ULK1 with an important role in hypoxic stress adaptation by promoting autophagy induction.

ORGANISM(S): Homo Sapiens

SUBMITTER: Rui Liu  

PROVIDER: PXD031209 | iProX | Tue Jan 25 00:00:00 GMT 2022

REPOSITORIES: iProX