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CLOCK regulates Drp1 mRNA stability and mitochondrial homeostasis by interacting with PUF60

ABSTRACT: This study demonstrated that circadian gene clock plays an important role in the regulation of mitochondrial homeostasis. In this process, CLOCK interacts with PUF60 and affects the mRNA stability of Drp1.

ORGANISM(S): Mus Musculus

SUBMITTER: Chao Lu

PROVIDER: PXD032057 | iProX | Thu Mar 31 00:00:00 BST 2022

REPOSITORIES: iProX

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CLOCK regulates Drp1 mRNA stability and mitochondrial homeostasis by interacting with PUF60.

Xu Lirong L Lin Jiaxin J Liu Yutong Y Hua Bingxuan B Cheng Qianyun Q Lin Changpo C Yan Zuoqin Z Wang Yaping Y Sun Ning N Qian Ruizhe R Lu Chao C

Cell reports 20220401 2

Circadian genes such as Clock, Bmal1, Cryptochrome1/2, and Period1/2/3 constitute the precise circadian system. ClockΔ19 is a commonly used mouse model harboring a circadian clock gene mutation, which lacks the EXON-19-encoded 51 amino acids. Previous reports have shown that ClockΔ19 mice have severe metabolic abnormalities. Here, we report that the mitochondria of ClockΔ19 mice exhibit excessive fission and dysfunction. We also demonstrate that CLOCK binds to th ...[more]

PMID: 35417690

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