Ontology highlight
ABSTRACT:
ORGANISM(S): Homo Sapiens
SUBMITTER: Fuquan Yang
PROVIDER: PXD032179 | iProX | Thu Mar 10 00:00:00 GMT 2022
REPOSITORIES: iProX
Li Na N An Peng P Wang Jifeng J Zhang Tingting T Qing Xiaoqing X Wu Bowen B Sun Lang L Ding Xiang X Niu Lili L Xie Zhensheng Z Zhang Mengmeng M Guo Xiaojing X Chen Xiulan X Cai Tanxi T Luo Jianming J Wang Fudi F Yang Fuquan F
iScience 20220316 4
The phenotype of β-thalassemia underlies multigene interactions, making clinical stratification complicated. An increasing number of genetic modifiers affecting the disease severity have been identified, but are still unable to meet the demand of precision diagnosis. Here, we systematically conducted a comparative plasma proteomic profiling on patients with β-thalassemia and healthy controls. Among 246 dysregulated proteins, 13 core protein signatures with excellent biomarker potential are propo ...[more]