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STK19 is not a kinase but a DNA-binding protein involved in DNA damage repair

ABSTRACT: STK19 is not a kinase but a DNA-binding protein involved in DNA damage repair

ORGANISM(S): Homo Sapiens

SUBMITTER: Lunzhi Dai

PROVIDER: PXD034123 | iProX | Wed May 25 00:00:00 BST 2022

REPOSITORIES: iProX

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STK19 is a DNA/RNA-binding protein critical for DNA damage repair and cell proliferation.

Li Yuling Y Gong Yanqiu Y Zhou Yue Y Xiao Yuzhou Y Huang Wenxin W Zhou Qiao Q Tu Yingfeng Y Zhao Yinglan Y Zhang Shuyu S Dai Lunzhi L Sun Qingxiang Q

The Journal of cell biology 20240122 2

STK19 was originally identified as a manganese-dependent serine/threonine-specific protein kinase, but its function has been highly debated. Here, the crystal structure of STK19 revealed that it does not contain a kinase domain, but three intimately packed winged helix (WH) domains. The third WH domain mediated homodimerization and double-stranded DNA binding, both being important for its nuclear localization. STK19 participated in the nucleotide excision repair (NER) and mismatch repair (MMR) p ...[more]

PMID: 38252411

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