Ontology highlight
ABSTRACT:
ORGANISM(S): Homo Sapiens
SUBMITTER: Hong Jiang
PROVIDER: PXD041365 | iProX | Wed Apr 05 00:00:00 BST 2023
REPOSITORIES: iProX
Yang Bo B Zhang Wentao W Sun Le L Lu Bin B Yin Changsong C Zhang Yaoyang Y Jiang Hong H
iScience 20230419 5
Creatine kinase (CK) is an essential metabolic enzyme mediating creatine/phosphocreatine interconversion and shuttle to replenish ATP for energy needs. Ablation of CK causes a deficiency in energy supply that eventually results in reduced muscle burst activity and neurological disorders in mice. Besides the well-established role of CK in energy-buffering, the mechanism underlying the non-metabolic function of CK is poorly understood. Here we demonstrate that creatine kinase brain-type (CKB) may ...[more]