Proteomics

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Analyze the post-translation modification of UVRAG

ABSTRACT: To explore the role of post-translational modification on UVRAG, we used tandem mass spectrometry (MS/MS) to analyze the UVRAG from cells.

ORGANISM(S): Homo Sapiens

SUBMITTER: Zhiyong Zhang  

PROVIDER: PXD034521 | iProX | Tue Jun 14 00:00:00 BST 2022

REPOSITORIES: iProX

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Publications

Targeting WDxR motif reprograms immune microenvironment and inhibits hepatocellular carcinoma progression.

Zhang Heng H   Chen Gang G   Feng Xing X   Feng Xing X   Song Huiwen H   Meng Lingbing L   Fu Yao Y   Yang Jun J   Fan Zhiwen Z   Ding Youxiang Y   Du Zhijie Z   Wang Jianchao J   Yang Li L   Zhang Jun J   Sun Lixia L   Liu Zhigang Z   Zhang Zhiyong Z   Li Quanhai Q   Fan Xiangshan X  

EMBO molecular medicine 20230322 5

The WD-repeat (WDR) family affects carcinogenesis, but its role in the immune microenvironment is poorly characterized. Although functional loss or gain of WDR6 does not markedly change in vitro proliferative and invasive capacity of HCC cells, its deficiency in hepa1-6 cells drastically inhibits the growth and lung metastasis of orthotopically implanted tumors in immune-competent C57BL/6J mice. Mechanistically, WDR6 targets tumor suppressor UVRAG to the CUL4A-DDB1-ROC1 E3 ubiquitin ligase compl  ...[more]

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