Proteomics

Dataset Information

0

Study on glycine regulation of serum resistance of Vibrio alginolyticus


ABSTRACT: Recently, we propose that metabolic state determines serum resistance. By comparing the serum-resistant and serum-sensitive bacteria, we find that glycine, serine and threonine metabolism is repressed in serum-resistant bacteria. To better understand how glycine sensitizes Vibrio to fish serum, we adopted quantitative proteomics to investigate the glycine-triggered proteomic change.

ORGANISM(S): Vibrio Alginolyticus 12g01

SUBMITTER: Bo Peng  

PROVIDER: PXD035517 | iProX | Fri Jul 22 00:00:00 BST 2022

REPOSITORIES: iProX

altmetric image

Publications

Functional proteomics identify mannitol metabolism in serum resistance and therapeutic implications in <i>Vibrio alginolyticus</i>.

Kou Tian-Shun TS   Wu Jia-Han JH   Chen Xuan-Wei XW   Peng Bo B  

Frontiers in immunology 20221031


Serum resistance is recognized as one of the most important pathogenic traits of bacterial pathogens, and no control measure is available. Based on our previous discovery that pathogenic <i>Escherichia coli</i> represses glycine, serine, and threonine metabolism to confer serum resistance and that the reactivation of this pathway by exogenous glycine could restore serum sensitivity, we further investigate the mechanism underlying the action of glycine in <i>Vibrio alginolyticus</i>. Thus, <i>V.  ...[more]

Similar Datasets

2011-12-31 | GSE24319 | GEO
2011-12-31 | E-GEOD-24319 | biostudies-arrayexpress
2020-05-26 | PXD014375 | Pride
2022-02-16 | PXD022551 | Pride
2021-12-06 | GSE125760 | GEO
| PRJNA841077 | ENA
| PRJNA40371 | ENA
2014-11-21 | MSV000078946 | MassIVE
| PRJNA566043 | ENA
| PRJNA566121 | ENA