Ontology highlight
ABSTRACT:
ORGANISM(S): Homo Sapiens
SUBMITTER: Qiao Wu
PROVIDER: PXD035911 | iProX | Tue Aug 09 00:00:00 BST 2022
REPOSITORIES: iProX
Chen Qi-Tao QT Zhang Zhi-Yuan ZY Huang Qiao-Ling QL Chen Hang-Zi HZ Hong Wen-Bin WB Lin Tianwei T Zhao Wen-Xiu WX Wang Xiao-Min XM Ju Cui-Yu CY Wu Liu-Zheng LZ Huang Ya-Ying YY Hou Pei-Pei PP Wang Wei-Jia WJ Zhou Dawang D Deng Xianming X Wu Qiao Q
Nature metabolism 20221003 10
Extracellular vesicles play crucial roles in intercellular communication in the tumor microenvironment. Here we demonstrate that in hepatic fibrosis, TGF-β stimulates the palmitoylation of hexokinase 1 (HK1) in hepatic stellate cells (HSCs), which facilitates the secretion of HK1 via large extracellular vesicles in a TSG101-dependent manner. The large extracellular vesicle HK1 is hijacked by hepatocellular carcinoma (HCC) cells, leading to accelerated glycolysis and HCC progression. In HSCs, the ...[more]