Proteomics

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Global Profiling of the Lysine Lactylation in Human Lung


ABSTRACT: LC-MS/MS for global profiling of lactylation in human lung under normal physiological conditions

ORGANISM(S): Homo Sapiens

SUBMITTER: Juntao Yang  

PROVIDER: PXD036307 | iProX | Thu Aug 25 00:00:00 GMT+01:00 2022

REPOSITORIES: iProX

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Publications

Global profiling of lysine lactylation in human lungs.

Yang Ye-Hong YH   Wang Qiao-Chu QC   Kong Jie J   Yang Jun-Tao JT   Liu Jiang-Feng JF  

Proteomics 20230512 15


Lactate is closely related to various cellular processes, such as angiogenesis, responses to hypoxia, and macrophage polarization, while regulating natural immune signaling pathways and promoting neurogenesis and cognitive function. Lysine lactylation (Kla) is a novel posttranslational modification, the examination of which may lead to new understanding of the nonmetabolic functions of lactate and the various physiological and pathological processes in which lactate is involved, such as infectio  ...[more]

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